Efficacy evaluation of a herbal anti-cellulite lotion: a phase 2

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Background: Cellulite is a cosmetic problem, especially in women. We compared the safety and efficacy of a herbal anti-cellulite lotion with a placebo in a randomized, double-blind, right-left comparison clinical trial.Methods: Ten healthy women (22-58 years) with cellulite (grades 2-4) participated in this study. The anti-cellulite lotion and placebo were applied twice daily on the thighs and buttocks for two months. Treated areas were photographed, and the thigh circumference, subcutaneous fat thickness, and dermal echo density were assessed and compared before and after the treatment. The satisfaction of the participants was also assessed.Results: A comparable improvement in cellulite grade was detected by a blinded dermatologist on both treatment sides. Cellulite improved much in one participant, improved in six, and did not change in three participants. The dermis thickness increased compared with placebo after two months (P = 0.046). A significant reduction was observed in subcutaneous fat thickness on the treated side (P = 0.03). However, the decrease was not significant on the placebo site. There was an increase in the echo density of the dermis in the treatment site, though it was not statistically significant. Both products were well tolerated, and none of the participants experienced skin burning or itching.Conclusion: The studied anti-cellulite lotion reduced the thickness of subcutaneous fat and increased the dermis thickness without serious adverse effects.